BOC-NLE-OSU

Base Information

• Chemical Name: BOC-NLE-OSU
• CAS No.: 36360-61-9
• Molecular Formula: C15H24 N2 O6
• Molecular Weight: 328.36
• Hs Code.: 2925190090
• Mol file: 36360-61-9.mol

Synonyms:BOC-NLE-OSU;BOC-NORLEUCINE-OSU;BOC-L-NORLEUCINE HYDROXYSUCCINIMIDE ESTER;BOC-L-NORLEUCINE N-HYDROXYSUCCINIMIDE ESTER;BOC-L-2-AMINOHEXANOIC ACID-N-HYDROXYSUCCINIMIDE ESTER;BOC-L-2-AMINOHEXANOIC ACID-OSU;BOC-L-NORLEUCINE HYDROXYSUCCINIMIDESTER

Chemical Property of BOC-NLE-OSU

Chemical Property:

• PSA: 102.01000
• LogP: 2.00590
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

BOC-NLE-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-NLE-OSU

There total 2 articles about BOC-NLE-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Nle-OH (6404-28-0) → BOC-L-norleucine succinimide (36360-61-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at -5 - 20 ℃; for 3h;

DOI:10.1006/bioo.1996.0034

Reference yield:

→ BOC-L-norleucine succinimide (36360-61-9)

Guidance literature:

Boc-NleH, N-Hydroxysuccinimid;

DOI:10.1016/0045-2068(71)90007-1

Reference yield:

N'-(tert-butoxycarbonyl)-N-[(S)-1-(hydroxymethyl)-3-methylbutyl]-L-tyrosinamide + BOC-L-norleucine succinimide (36360-61-9) → N'-[N-(tert-butoxycarbonyl)-L-norleucyl]-N-[(S)-1-(hydroxymethyl)-3-methylbutyl]-L-tyrosinamide

Guidance literature:

With hydrogenchloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Nle-OH

Downstream raw materials:

N^α-(tert-butyloxycarbonyl)-L-norleucyl-L-aspartic acid β-benzyl ester

Boc-Tyr(SO₃K)-Nle-gGly-D-Trp-D-Nle-D-Asp-COCH₂CH₂C₆H₅

Boc-Tyr(SO₃K)-Nle-Gly-Trp-Nle-Asp-gPhe-For

Boc-Nle-gGly-D-Trp-Z