H-Leu-Glu-OH

Base Information

• Chemical Name: H-Leu-Glu-OH
• CAS No.: 16364-31-1
• Molecular Formula: C₁₁H₂₀N₂O₅
• Molecular Weight: 260.29
• DSSTox Substance ID: DTXSID40876600
• Nikkaji Number: J3.002.923B
• Wikidata: Q27144710
• Metabolomics Workbench ID: 78862
• Mol file: 16364-31-1.mol

Synonyms:H-Leu-Glu-OH;16364-31-1;leucylglutamic acid;L-LEUCYL-L-GLUTAMIC ACID;Leu-Glu;L-Glutamic acid,L-leucyl-;(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]pentanedioic acid;Leucyl-Glutamate;(S)-2-((S)-2-Amino-4-methylpentanamido)pentanedioic acid;Leucyl-glutamic acid;L-Leu-L-Glu;L-Leucyl-Glutaminsaure;SCHEMBL14941316;CHEBI:74531;DTXSID40876600;le;MFCD00037302;AKOS010408432;L-GLUTAMIC ACID, N-L-LEUCYL-;Q27144710

Chemical Property of H-Leu-Glu-OH

Chemical Property:

• Boiling Point: 517.3±50.0 °C(Predicted)
• PKA: 3.03±0.10(Predicted)
• PSA: 129.72000
• Density: 1.28 g/cm3
• LogP: 0.88520
• Storage Temp.: -15°C
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 260.13722174
• Heavy Atom Count: 18
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

LEU-GLU-OH 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)O)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)N
• Recent ClinicalTrials: Tear Fluid Levels of Loteprednol Etabonate Ophthalmic Gel 0.5% Following a Single Instillation
• Uses: Application of nonpolar dipeptide for preparing antihypertensive drug or health care product.

Technology Process of H-Leu-Glu-OH

There total 17 articles about H-Leu-Glu-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.57%

Boc-Leu-Glu(OH)2 → N-L-leucyl-L-glutamic acid (16364-31-1,38062-67-8)

Guidance literature:

With trifluoroacetic acid; for 8h;

DOI:10.1039/c1ob05757j

Reference yield:

Leu-Glu-4-methycoumaryl-7-amide (929621-98-7) → N-L-leucyl-L-glutamic acid (16364-31-1,38062-67-8)

Guidance literature:

With ethylenediaminetetraacetic acid; dipeptydyl-peptidase DPP₁₁; sodium phosphate; sodium chloride; In water; at 37 ℃; for 0.5h; pH=7.0; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1074/jbc.M113.527333

Reference yield:

(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-pentanedioic acid dibenzyl ester → N-L-leucyl-L-glutamic acid (16364-31-1,38062-67-8)

Guidance literature:

With hydrogen; palladium on activated charcoal;

upstream raw materials:

(R)-2-Bromo-4-methyl-pentanoyl chloride

D-Glutamic acid

L-glutamic acid

2-bromo-4-methylpentanoyl chloride