[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester
CAS No.:1027367-46-9
Molecular Formula:C₂₀H₂₉N₃O₄
Molecular Weight:375.468
Hs Code.:

Synonyms:[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

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Technology Process of [(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

There total 1 articles about [(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 134037-95-9
Cbz-L-Leucine fluoride

: (3S,4R)-3-Amino-4-isopropyl-azetidin-2-one

: 1027367-46-9
[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; for 1h;
DOI:10.1039/CC9960000633

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1027367-46-9
[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

: 176217-51-9
(2R,3S)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-isopropyl-4-oxo-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; In acetonitrile; for 12h; Ambient temperature;
DOI:10.1039/CC9960000633

Reference yield:

: 1027367-46-9
[(S)-1-((2R,3S)-2-Isopropyl-4-oxo-azetidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

: (S)-2-[(2S,3S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-tert-butoxycarbonylamino-4-methyl-pentanoylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DMAP / acetonitrile / 12 h / Ambient temperature

2: 75 percent / NaN₃ / dimethylformamide / 14 h / Ambient temperature

With dmap; sodium azide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/CC9960000633