FA-PHE-OH

Base Information

• Chemical Name: FA-PHE-OH
• CAS No.: 71115-83-8
• Molecular Formula: C16H15 N O4
• Molecular Weight: 285.29
• Hs Code.: 2932190090
• Mol file: 71115-83-8.mol

Synonyms:L-Phenylalanine,N-[3-(2-furanyl)-1-oxo-2-propenyl]- (9CI); 2-Furanacryloyl-L-phenylalanine

Chemical Property of FA-PHE-OH

Chemical Property:

• PSA: 79.54000
• LogP: 2.49580
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

2-Furanacryloyl-L-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Furanacryloyl-L-phenylalanine can be used to detect angiotensin converting enzyme inhibitors on 96 well plates.

Technology Process of FA-PHE-OH

There total 15 articles about FA-PHE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycinamide hydrochloride (1668-10-6) + N-<3-(2-furyl)acryloyl>phenylalanine ethyl ester → N-<3-(2-furyl)acryloyl>-Phe (71115-83-8) + N-<3-(2-furyl)acryloyl>-Phe-Gly-NH2 (90846-39-2)

Guidance literature:

carboxypeptidase from yeast (CPase-Y); In N,N-dimethyl-formamide; at 30 ℃; for 3h; under 1500120 Torr; pH=8.0;

DOI:10.1246/bcsj.62.514

Reference yield:

(S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) + N-<3-(2-furyl)acryloyl>phenylalanine ethyl ester → N-<3-(2-furyl)acryloyl>-Phe (71115-83-8) + N-<3-(2-furyl)acryloyl>-Phe-Phe-NH2 (26390-02-3) + 3-(2-furyl)acryloylglycyl-L-phenylalanine-L-phenylalanine (83661-95-4)

Guidance literature:

carboxypeptidase from yeast (CPase-Y); In N,N-dimethyl-formamide; at 30 ℃; for 3h; under 1500120 Torr; pH=8.0;

DOI:10.1246/bcsj.62.514

Reference yield:

N-<3-(2-furyl)acryloyl>-Phe-Phe-NH2 (26390-02-3) → N-<3-(2-furyl)acryloyl>-Phe (71115-83-8) + 3-(2-furyl)acryloylglycyl-L-phenylalanine-L-phenylalanine (83661-95-4)

Guidance literature:

With carboxypeptidase W; at 25 ℃; Product distribution; pH = 7.5; various pH-s, enzymes;

DOI:10.1246/bcsj.60.1399

upstream raw materials:

N-<3-(2-furyl)acryloyl>-Phe-Phe-NH2

H-L-Leu-NH₂

L-Phenylalanine amide

H-Gly-NH₂

Downstream raw materials:

C₂₀H₁₈N₂O₆

C₂₇H₂₅N₃O₅

FA-Phe-Ile

FA-Phe-Met

Refernces

• 1、 Shima, Hiroshi,Fukuda, Mitsuhiro,Tanabe, Kazuo,Ito, Takanobu,Kunugi, Shigeru. "Wheat Carboxypeptidase-Catalyzed Peptide Synthesis by Aminolysis of N-Acyl Amino Acid Ester. Indication of the Acyl-Enzyme Mechanism". . p. 1403 - 1406. Retrieved 1987.
• 2、 Kunugi, Shigeru,Tanabe, Kazuo,Yamashita, Kouji,Morikawa, Yoshio,Ito, Takanobu,et al.. "Protease-Catalyzed Peptide Formation under High Pressure". . p. 514 - 518. Retrieved 2007/10/02.