BOC-1,2-TRANS-ACHC-OH

Base Information

• Chemical Name: BOC-1,2-TRANS-ACHC-OH
• CAS No.: 209128-50-7
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Hs Code.: 2924297099
• Mol file: 209128-50-7.mol

Synonyms:BOC-1,2-TRANS-ACHC-OH;BOC-(+/-)-TRANS-2-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID;BOC-TRANS-2-AMINOCYCLOHEXANECARBOXYLIC ACID;BOC-TRANS-1,2-AMINOCYCLOHEXANE CARBOXYLIC ACID;TRANS-2-(BOC-AMINO)-CYCLOHEXANECARBOXYLIC ACID;TRANS-2-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID;TRANS-1-(TERT-BUTYLOXYCARBONYL-AMINO)-CYCLOHEXYL-2-CARBOXYLIC ACID;TRANS-1-(T-BUTYLOXYCARBONYL-AMINO)-CYCLOHEXYL-2-CARBOXYLIC ACID

Chemical Property of BOC-1,2-TRANS-ACHC-OH

Chemical Property:

• Vapor Pressure: 2.12E-07mmHg at 25°C
• Boiling Point: 396.7°C at 760 mmHg
• PKA: 4.95±0.28(Predicted)
• Flash Point: 193.7°C
• PSA: 75.63000
• Density: 1.12g/cm³
• LogP: 2.54540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-trans-2-aminocyclohexanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-1,2-TRANS-ACHC-OH

There total 30 articles about BOC-1,2-TRANS-ACHC-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl (1R,2R)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate (267230-27-3) → (1R,2R)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid (233661-54-6,209128-50-7)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In methanol; at 20 ℃; for 36h;

DOI:10.1021/ja0270423

Reference yield: 97.0%

Methyl (1R,2R)-N-tert-butyloxycarbonyl-trans-2-aminocyclohexanecarboxylate → N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid (220760-49-6,209128-50-7)

Guidance literature:

With hydrogenchloride; aqueous H₂O₂; sodium sulfate; In methanol; water; ethyl acetate;

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (-)-(1R,2S)-2-aminocyclohexanecarboxylic acid hydrochloride (158414-45-0) → (1S,2R)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid (865689-36-7,209128-50-7)

Guidance literature:

With triethylamine; In dichloromethane; at 5 ℃; for 3h;

upstream raw materials:

1,2-cis-cyclohexanedicarboxylic anhydride

tert-butyl alcohol

di-tert-butyl dicarbonate

(1RS,2SR)-2-aminocyclohexanecarboxylic acid

Downstream raw materials:

(±)-trans-2-aminocyclohexanecarboxylic acid hydrochloride