L-Alanyl-L-norleucine

Base Information

• Chemical Name: L-Alanyl-L-norleucine
• CAS No.: 3303-37-5
• Molecular Formula: C9H18N2O3
• Molecular Weight: 202.25
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID101314643
• Nikkaji Number: J253.836I
• ChEMBL ID: CHEMBL1814488
• Mol file: 3303-37-5.mol

Synonyms:L-ALANYL-L-NORLEUCINE;H-ALA-NLE-OH;3303-37-5;Norleucine, alanyl-;CHEMBL1814488;L-Norleucine,L-alanyl-;(2S)-2-[[(2S)-2-aminopropanoyl]amino]hexanoic acid;SCHEMBL15757005;CHEBI:183924;DTXSID101314643;BDBM50350462;AKOS024337852;(S)-2-((S)-2-aminopropanamido)hexanoic acid;(S)-2-[[(S)-2-Aminopropanoyl]amino]hexanoic acid

Chemical Property of L-Alanyl-L-norleucine

Chemical Property:

• Boiling Point: 417.6 °C at 760 mmHg
• Flash Point: 206.3 °C
• PSA: 92.42000
• Density: 1.11g/cm³
• LogP: 1.18440
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 202.13174244
• Heavy Atom Count: 14
• Complexity: 206

Purity/Quality:

99% ^*data from raw suppliers

ALA-NLE-OH 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(C(=O)O)NC(=O)C(C)N
• Isomeric SMILES: CCCC[C@@H](C(=O)O)NC(=O)[C@H](C)N

Technology Process of L-Alanyl-L-norleucine

There total 1 articles about L-Alanyl-L-norleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-(S)-2-aminohexanoic acid (77284-32-3,144701-20-2) → alanylnorleucine (3303-37-5)

Guidance literature:

Fmoc-(S)-2-aminohexanoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

With piperidine; In N,N-dimethyl-formamide; for 0.5h;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Further stages;

DOI:10.1002/anie.202005070

Reference yield:

4-formyl-benzenesulfonamide (3240-35-5) + alanylnorleucine (3303-37-5) → (S)-2-((S)-2-((4-sulfamoylbenzyl)amino)propanamido)hexanoic acid

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; pH=4 - 5;

DOI:10.1002/anie.202005070

upstream raw materials:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-(S)-2-aminohexanoic acid