Fmoc-L-norleucine

Base Information

Chemical Name:Fmoc-L-norleucine
CAS No.:77284-32-3
Molecular Formula:C21H23NO4
Molecular Weight:353.418
Hs Code.:2924 29 70
European Community (EC) Number:692-798-8
DSSTox Substance ID:DTXSID40426568
Nikkaji Number:J1.882.596A
Wikidata:Q69756964
Mol file:77284-32-3.mol

Synonyms:Fmoc-Nle-OH;Fmoc-L-norleucine;77284-32-3;(S)-2-(Fmoc-amino)caproic acid;N-Fmoc-L-norleucine;(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid;N-(9-Fluorenylmethoxycarbonyl)-L-norleucine;MFCD00037537;Fmoc-norleucine;FmocNleOH;Fmoc-(S)-2-aminohexanoic acid;Fmoc-Nle;Fmoc-Ahx-OH;Fmoc-L-Nle-OH;(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID;Fmoc-L-2-aminocaproic acid;Fmoc-L-norleucine Fmoc-Nle-OH;SCHEMBL1000115;DTXSID40426568;VCFCFPNRQDANPN-IBGZPJMESA-N;BBL102853;STL556661;AKOS016842954;AM82590;CS-W009404;HY-W008688;AS-18993;N-(9H-Fluorene-9-ylmethoxycarbonyl)norleucine;EN300-316895;N-[(9H-fluoren-9-ylmethoxy)carbonyl]norleucine;AU-004/43510510;J-300350;N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine;N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-norleucine;Q-101634;Fmoc-Nle-OH, >=98.0% (sum of enantiomers, HPLC);Z1900782536;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)hexanoic acid;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid

Suppliers and Price of Fmoc-L-norleucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-L-norleucine
10g
$ 370.00

TRC
Fmoc-Nle-OH
250mg
$ 55.00

Sigma-Aldrich
Fmoc-Nle-OH Novabiochem?
25 g
$ 280.00

Sigma-Aldrich
Fmoc-Nle-OH Novabiochem . CAS 77284-32-3, molar mass 353.41 g/mol., Novabiochem
8520140025
$ 270.00

Sigma-Aldrich
Fmoc-Nle-OH Novabiochem?
5 g
$ 74.30

Sigma-Aldrich
Fmoc-Nle-OH Novabiochem . CAS 77284-32-3, molar mass 353.41 g/mol., Novabiochem
8520140005
$ 71.80

Sigma-Aldrich
Fmoc-Nle-OH ≥98.0% (sum of enantiomers, HPLC)
1g
$ 53.80

Matrix Scientific
Fmoc-L-2-aminocaproic acid
5g
$ 41.00

Matrix Scientific
Fmoc-L-2-aminocaproic acid
25g
$ 145.00

Matrix Scientific
Fmoc-L-2-aminocaproic acid
100g
$ 436.00

Total 97 raw suppliers

Chemical Property of Fmoc-L-norleucine

Chemical Property:

Vapor Pressure:1.25E-13mmHg at 25°C
Melting Point:141-144 °C
Boiling Point:565.6 °C at 760 mmHg
PKA:3.91±0.21(Predicted)
Flash Point:295.9 °C
PSA：75.63000
Density:1.209 g/cm³
LogP:4.55940
Storage Temp.:2-8°C
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:353.16270821
Heavy Atom Count:26
Complexity:472

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-L-norleucine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES:CCCC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Uses Fmoc-Nle-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

Technology Process of Fmoc-L-norleucine

There total 5 articles about Fmoc-L-norleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144701-20-2
Fmoc-norleucine

: 77284-32-3,144701-20-2
Fmoc-(S)-2-aminohexanoic acid

: 112883-41-7,144701-20-2
(R)-((9H-fluoren-9-yl)methoxy)carbonyl-D-norleucine

Guidance literature:: With trifluoroacetic acid; In hexane; isopropyl alcohol; at 25 ℃; Reagent/catalyst; Resolution of racemate;
DOI:10.1002/bkcs.11694

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 77284-32-3,144701-20-2
Fmoc-(S)-2-aminohexanoic acid

: 112883-41-7,144701-20-2
(R)-((9H-fluoren-9-yl)methoxy)carbonyl-D-norleucine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice

1.2: 5 h / 20 °C

2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate

With sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; hexane; water; isopropyl alcohol;
DOI:10.1002/bkcs.11694

Reference yield:

: 616-06-8
2-amino-hexanoic acid

: 77284-32-3,144701-20-2
Fmoc-(S)-2-aminohexanoic acid

: 112883-41-7,144701-20-2
(R)-((9H-fluoren-9-yl)methoxy)carbonyl-D-norleucine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice

1.2: 5 h / 20 °C

2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate

With sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; hexane; water; isopropyl alcohol;
DOI:10.1002/bkcs.11694