2-[5-(Tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile

Base Information

• Chemical Name: 2-[5-(Tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile
• CAS No.: 145733-55-7
• Molecular Formula: C₁₉H₂₄N₂OSi
• Molecular Weight: 324.498
• DSSTox Substance ID: DTXSID901139196
• Mol file: 145733-55-7.mol

Synonyms:SCHEMBL8804061;YKFNTABAUAUVBE-UHFFFAOYSA-N;DTXSID901139196;2-[5-(tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile;2-[5-(tert-Butyldimethylsilyloxymethyl)pyridin-2-yl]benzonitrile;2-[5-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-2-pyridinyl]benzonitrile;145733-55-7

Chemical Property of 2-[5-(Tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 324.165789928
• Heavy Atom Count: 23
• Complexity: 434

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCC1=CN=C(C=C1)C2=CC=CC=C2C#N

Technology Process of 2-[5-(Tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile

There total 5 articles about 2-[5-(Tert-butyldimethylsiloxymethyl)pyridin-2-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,2-dimethylmalononitrile (7321-55-3) + C18H25NOSi → 2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile (145733-55-7)

Guidance literature:

With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; copper(II) oxide; at 160 ℃; for 24h;

DOI:10.1039/c8cc08930b

Reference yield:

6-bromonicotinic acid (6311-35-9) → 2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile (145733-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / BH₃ / tetrahydrofuran / 3 h / Ambient temperature

2: 97 percent / dimethylformamide / 1 h

3: 1.) n-BuLi, 2.) tri-n-butyltin chloride, 3.) CuI, bis(triphenylphosphine)palladium(II) chloride

With copper(l) iodide; n-butyllithium; bis(triphenylphosphine)palladium(II)-chloride; borane; tributyltin chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00030a013

Reference yield:

2-bromo-5-(hydroxymethyl)pyridine (122306-01-8) → 2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile (145733-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / dimethylformamide / 1 h

2: 1.) n-BuLi, 2.) tri-n-butyltin chloride, 3.) CuI, bis(triphenylphosphine)palladium(II) chloride

With copper(l) iodide; n-butyllithium; bis(triphenylphosphine)palladium(II)-chloride; tributyltin chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00030a013

upstream raw materials:

2-iodobenzonitrile

2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

6-bromonicotinic acid

2-bromo-5-(hydroxymethyl)pyridine

Downstream raw materials:

2-<5-(hydroxymethyl)pyridin-2-yl>benzonitrile

2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

5,8-dihydro-2,4-dimethyl-8-<<6-(2-cyanophenyl)-3-pyridinyl>methyl>pyrido<2,3-d>pyrimidin-7(6H)-one

2-<5-(chloromethyl)pyridin-2-yl>benzonitrile