(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

Base Information

Chemical Name:(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate
CAS No.:1360217-63-5
Molecular Formula:C₁₇H₁₅NO₃
Molecular Weight:281.311
Hs Code.:

Synonyms:(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

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Chemical Property of (S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of (S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

There total 4 articles about (S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₃NO₃Si

: 1360217-63-5
(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/c2cc17830c

Reference yield:

: 1253043-91-2
(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

: 1360217-63-5
(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1039/c2cc17830c

Reference yield:

: 1253043-95-6
1-iodo-2-(3-iodoprop-1-ynyl)benzene

: 1360217-63-5
(S)-methyl 1-(3-(2-ethynylphenyl)prop-2-ynyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1002/adsc.201200045