(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester
CAS No.:1253043-91-2
Molecular Formula:C₁₅H₁₄INO₃
Molecular Weight:383.186
Hs Code.:

Synonyms:(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

There total 1 articles about (S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1253043-95-6
1-iodo-2-(3-iodoprop-1-ynyl)benzene

: 4931-66-2
methyl (S)-pyroglutamate

: 1253043-91-2
(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/ja106668d

Reference yield:

: 1253043-91-2
(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

: 1066-54-2
trimethylsilylacetylene

: C₂₀H₂₃NO₃Si

Guidance literature:: (S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

trimethylsilylacetylene; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c2cc17830c

Reference yield:

: 1253043-91-2
(S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester

: 107-19-7
propargyl alcohol

: 1253043-92-3
(S)-1-{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}-5-oxopyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: (S)-1-[3-(2-iodophenyl)prop-2-ynyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

propargyl alcohol; With triethylamine; In tetrahydrofuran; at 40 ℃; for 19h; Inert atmosphere;
DOI:10.1021/ja106668d