(2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime)

Base Information

• Chemical Name: (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime)
• CAS No.: 886462-41-5
• Molecular Formula: C₂₃H₃₀N₂O₄
• Molecular Weight: 398.502
• Mol file: 886462-41-5.mol

Synonyms:(2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime)

Chemical Property of (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime)

There total 5 articles about (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1R,2R,5R,6R)-1,5-Dimethyl-2,6-diphenyl-3,7-dioxa-bicyclo[3.3.1]nonane-2,6-diol + N-methoxylamine hydrochloride (593-56-6) → (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime) (886462-41-5)

Guidance literature:

With pyridine; N-methoxylamine hydrochloride; at 95 ℃; for 10h;

DOI:10.1016/j.tetlet.2006.02.038

Reference yield:

(1R,2R,5R,6R)-1,5-Dimethyl-2,6-diphenyl-3,7-dioxa-bicyclo[3.3.1]nonane-2,6-diol → (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime) (886462-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: concd. H₂SO₄ / CHCl₃ / Heating

2: concd. H₂SO₄; H₂O / acetone; tetrahydrofuran / 0.5 h / Heating

3: 90 percent / MeONH₂*HCl; pyridine / 10 h / 95 °C

With pyridine; sulfuric acid; water; N-methoxylamine hydrochloride; In tetrahydrofuran; chloroform; acetone;

DOI:10.1016/j.tetlet.2006.02.038

Reference yield:

(1R,2R,5R,6R)-2,6-Diethoxy-1,5-dimethyl-2,6-diphenyl-3,7-dioxa-bicyclo[3.3.1]nonane → (2R,4R)-2,4-Bis-hydroxymethyl-2,4-dimethyl-1,5-diphenyl-pentane-1,5-dione bis-(O-methyl-oxime) (886462-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: concd. H₂SO₄; H₂O / acetone; tetrahydrofuran / 0.5 h / Heating

2: 90 percent / MeONH₂*HCl; pyridine / 10 h / 95 °C

With pyridine; sulfuric acid; water; N-methoxylamine hydrochloride; In tetrahydrofuran; acetone;

DOI:10.1016/j.tetlet.2006.02.038

upstream raw materials:

N-methoxylamine hydrochloride

2,4-dimethyl-1,5-diphenylpropan-1,5-dione

1-phenyl-propan-1-one

Downstream raw materials:

(1R,2R,5R,6R)-3,7-Dimethoxy-1,5-dimethyl-2,6-diphenyl-3,7-diaza-bicyclo[3.3.1]nonane-2,6-diol

(1R,2S,5R,6S)-3,7-Dimethoxy-1,5-dimethyl-2,6-diphenyl-3,7-diaza-bicyclo[3.3.1]nonane

(4S,5R,7R,8S)-5,7-Dimethyl-4,8-diphenyl-1,3-diaza-tricyclo[3.3.1.1^3,7]decane

(1R,2S,5R,6S)-1,5-Dimethyl-2,6-diphenyl-3,7-diaza-bicyclo[3.3.1]nonane