(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

Base Information

Chemical Name:(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran
CAS No.:501012-28-8
Molecular Formula:C₂₉H₃₃FO₇
Molecular Weight:512.575
Hs Code.:

Synonyms:(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

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Chemical Property of (2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

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Technology Process of (2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

There total 13 articles about (2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 82297-89-0
(4-fluoro-3-methyl)phenylmagnesium bromide

: 501012-25-5
(2R,3S,4S)-4-hydroxy-3-(p-methoxybenzyloxy)-4-(p-methoxybenzyloxymethyl)tetrahydrofuran-2-carbaldehyde

: 501012-28-8
(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 12h;

Reference yield: 85.0%

: 501012-28-8
(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

Guidance literature:

Reference yield:

: 225233-48-7
4-C-hydroxymethyl-1,2-O-isopropylidene-3,5-di-O-p-methoxybenzyl-α-D-ribo-pentofuranose

: 501012-28-8
(2S,3S,4S)-4-hydroxy-2-[(R)-hydroxy(4-fluoro-3-methylphenyl)methyl]-4-(p-methoxybenzyloxy)-3-(p-methoxybenzyloxymethyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / pyridine / 20 °C

2: aq. HCl / 72 h / 20 °C

3: NaH / dimethylformamide; various solvent(s) / 12 h / 20 °C

4: 82 percent / aq. AcOH / 4 h / 50 °C

5: 85 percent / tetrahydrofuran / 12 h / 0 °C

With pyridine; hydrogenchloride; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; 5: Grignard reaction;