N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine

Base Information

• Chemical Name: N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine
• CAS No.: 681836-64-6
• Molecular Formula: C₂₇H₃₀N₈O
• Molecular Weight: 482.588

Synonyms:N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine

Chemical Property of N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine

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Technology Process of N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine

There total 3 articles about N-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N4-[3-(benzyloxy)phenyl]-N,N-dimethyl-2-(methylsulfinyl)-4,6-pyrimidinediamine (681836-65-7) + 1-(2-pyrimidyl)piperazine dihydrochloride (94021-22-4) → N-[3-(benzyloxy)phenyl]-N6,N6-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine (681836-64-6)

Guidance literature:

In chlorobenzene; for 15h; Heating / reflux;

Reference yield:

N-[6-chloro-2-(methylsulfanyl)-4-pyrimidinyl]-N,N-dimethylamine (161611-29-6) → N-[3-(benzyloxy)phenyl]-N6,N6-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine (681836-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / Heating / reflux

1.2: 22.5 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

3.1: chlorobenzene / 15 h / Heating / reflux

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; chlorobenzene;

Reference yield:

N4-[3-(benzyloxy)phenyl]-N6,N6-dimethyl-2-(methylsulfanyl)-4,6-pyrimidinediamine (681836-63-5) → N-[3-(benzyloxy)phenyl]-N6,N6-dimethyl-2-[4-(2-pyrimidinyl)-1-piperazinyl]-4,6-pyrimidinediamine (681836-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

2: chlorobenzene / 15 h / Heating / reflux

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chlorobenzene;

upstream raw materials:

N₄-[3-(benzyloxy)phenyl]-N,N-dimethyl-2-(methylsulfinyl)-4,6-pyrimidinediamine

1-(2-pyrimidyl)piperazine dihydrochloride

N-[6-chloro-2-(methylsulfanyl)-4-pyrimidinyl]-N,N-dimethylamine

N₄-[3-(benzyloxy)phenyl]-N₆,N₆-dimethyl-2-(methylsulfanyl)-4,6-pyrimidinediamine

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