2-Chloro-N-(2,6-dichloro-4-Methoxyphenyl)-N-phenylacetaMide

Base Information

• Chemical Name: 2-Chloro-N-(2,6-dichloro-4-Methoxyphenyl)-N-phenylacetaMide
• CAS No.: 136099-58-6
• Molecular Formula: C₁₅H₁₂Cl₃NO₂
• Molecular Weight: 344.625
• Mol file: 136099-58-6.mol

Synonyms:N-[(2,6-dichloro-4-methoxy)phenyl]-N-phenyl chloroacetamide

Chemical Property of 2-Chloro-N-(2,6-dichloro-4-Methoxyphenyl)-N-phenylacetaMide

Chemical Property:

• Boiling Point: 534.9±50.0 °C(Predicted)
• PKA: -4.75±0.50(Predicted)
• Density: 1.395±0.06 g/cm3(Predicted)
• Solubility.: Chloroform, Methanol. DCM

Purity/Quality:

2-Chloro-N-(2,6-dichloro-4-methoxyphenyl)-N-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Chloro-N-(2,6-dichloro-4-methoxyphenyl)-N-phenylacetamide is an intermediate in the synthesis of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.

Technology Process of 2-Chloro-N-(2,6-dichloro-4-Methoxyphenyl)-N-phenylacetaMide

There total 1 articles about 2-Chloro-N-(2,6-dichloro-4-Methoxyphenyl)-N-phenylacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Phenyl-(2,6-dichloro-4-methoxy)-aniline (136099-56-4) + chloroacetyl chloride (79-04-9) → N-[(2,6-dichloro-4-methoxy)phenyl]-N-phenyl chloroacetamide (136099-58-6)

Guidance literature:

Reference yield: 87.0%

N-[(2,6-dichloro-4-methoxy)phenyl]-N-phenyl chloroacetamide (136099-58-6) → 1-[(2,6-Dichloro-4-hydroxy)phenyl]-1,3-dihydro-2H-indol-2-one (73328-71-9)

Guidance literature:

aluminium trichloride; In water;

upstream raw materials:

N-Phenyl-(2,6-dichloro-4-methoxy)-aniline

chloroacetyl chloride

Downstream raw materials:

1-[(2,6-Dichloro-4-hydroxy)phenyl]-1,3-dihydro-2H-indol-2-one

Refernces