Technology Process of tert-butyl (1S,2R)-2-(4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate
There total 7 articles about tert-butyl (1S,2R)-2-(4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 6-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate;
With
hydrogen; acetic acid;
palladium on carbon;
In
methanol;
at 20 ℃;
under 760.051 Torr;
With
sodium hydrogencarbonate;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C
1.2: -78 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
3.1: ISOPROPYLAMIDE / 140 °C
4.1: potassium fluoride / trans-bis(triphenylphosphine)palladium dichloride / 1,2-dimethoxyethane / 1 h / 120 °C / Microwave irradiation
5.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / dichloromethane / 7 h / 0 - 20 °C
6.1: trichlorophosphate / 5 h / 80 °C
7.1: triethylamine / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation
8.1: hydrogen; acetic acid / palladium on carbon / methanol / 20 °C / 760.05 Torr
With
potassium fluoride; n-butyllithium; hydrogen; urea hydrogen peroxide adduct; potassium carbonate; acetic acid; triethylamine; diisopropylamine; trifluoroacetic anhydride; trichlorophosphate;
trans-bis(triphenylphosphine)palladium dichloride; palladium on carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
2: ISOPROPYLAMIDE / 140 °C
3: potassium fluoride / trans-bis(triphenylphosphine)palladium dichloride / 1,2-dimethoxyethane / 1 h / 120 °C / Microwave irradiation
4: trifluoroacetic anhydride; urea hydrogen peroxide adduct / dichloromethane / 7 h / 0 - 20 °C
5: trichlorophosphate / 5 h / 80 °C
6: triethylamine / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation
7: hydrogen; acetic acid / palladium on carbon / methanol / 20 °C / 760.05 Torr
With
potassium fluoride; hydrogen; urea hydrogen peroxide adduct; potassium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; trichlorophosphate;
trans-bis(triphenylphosphine)palladium dichloride; palladium on carbon;
In
methanol; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;
3: Suzuki Coupling;
