6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

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Chemical Name:6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one
CAS No.:1312691-29-4
Molecular Formula:C₁₇H₂₂N₆O
Molecular Weight:326.401
Hs Code.:

Synonyms:6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

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Chemical Property of 6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

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Technology Process of 6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

There total 8 articles about 6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1312691-27-2
tert-butyl (1S,2R)-2-(4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate

: 1312691-29-4
6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1312691-24-9
methyl 6-chloro-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate

: 1312691-29-4
6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation

2: hydrogen; acetic acid / palladium on carbon / methanol / 20 °C / 760.05 Torr

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on carbon; In methanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 78607-36-0
2-chloro-3-iodopyridine

: 1312691-29-4
6-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: ISOPROPYLAMIDE / 140 °C

4.1: potassium fluoride / trans-bis(triphenylphosphine)palladium dichloride / 1,2-dimethoxyethane / 1 h / 120 °C / Microwave irradiation

5.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / dichloromethane / 7 h / 0 - 20 °C

6.1: trichlorophosphate / 5 h / 80 °C

7.1: triethylamine / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation

8.1: hydrogen; acetic acid / palladium on carbon / methanol / 20 °C / 760.05 Torr

9.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium fluoride; n-butyllithium; hydrogen; urea hydrogen peroxide adduct; potassium carbonate; acetic acid; triethylamine; diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; trichlorophosphate; trans-bis(triphenylphosphine)palladium dichloride; palladium on carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;