2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

Base Information

Chemical Name:2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid
CAS No.:1400705-66-9
Molecular Formula:C₁₅H₁₇N₃O₃
Molecular Weight:287.318
Hs Code.:

Synonyms:2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

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Chemical Property of 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

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Technology Process of 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

There total 4 articles about 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1400705-65-8
2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

: 1400705-66-9
2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

Guidance literature:: 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 90 ℃; for 12h;

With potassium hydrogensulfate; In 1,4-dioxane; water; at 20 ℃; pH=~ 2 - 4;

Reference yield:

: 108381-23-3
2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

: 1400705-66-9
2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / ethanol / 1 h / 150 °C / microwave irradiation

2.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 12 h / 90 °C

2.2: 20 °C / pH ~ 2 - 4

With lithium hydroxide monohydrate; water; potassium acetate; In 1,4-dioxane; ethanol;

Reference yield:

: 168130-75-4
4,6-dimethyl-2-hydroxypyrimidine-5-carboxylic acid ethyl ester

: 1400705-66-9
2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 110 °C

2.1: potassium acetate / ethanol / 1 h / 150 °C / microwave irradiation

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 12 h / 90 °C

3.2: 20 °C / pH ~ 2 - 4

With lithium hydroxide monohydrate; water; potassium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; ethanol;