2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

Base Information

• Chemical Name: 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester
• CAS No.: 1400705-65-8
• Molecular Formula: C₁₇H₂₁N₃O₃
• Molecular Weight: 315.372
• Mol file: 1400705-65-8.mol

Synonyms:2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

Chemical Property of 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

There total 4 articles about 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester (108381-23-3) + tyramine hydrochloride (60-19-5) → 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester (1400705-65-8)

Guidance literature:

With potassium acetate; In ethanol; at 150 ℃; for 1h; microwave irradiation;

Reference yield:

ethyl acetoacetate (141-97-9) → 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester (1400705-65-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid / ethanol / 90 °C

2.1: nitric acid / 0.25 h / 0 °C

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 110 °C

4.1: potassium acetate / ethanol / 1 h / 150 °C / microwave irradiation

With nitric acid; potassium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; acetic acid; In ethanol;

Reference yield:

4,6-dimethyl-2-hydroxypyrimidine-5-carboxylic acid ethyl ester (168130-75-4) → 2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester (1400705-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 110 °C

2: potassium acetate / ethanol / 1 h / 150 °C / microwave irradiation

With potassium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol;

upstream raw materials:

ethyl acetoacetate

2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

tyramine hydrochloride

4,6-dimethyl-2-hydroxypyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid