4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:1401225-06-6
Molecular Formula:C₂₀H₁₄F₃N₅O₂
Molecular Weight:413.359
Hs Code.:

Synonyms:4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 3 articles about 4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401224-91-6
4-{4-methyl-2,5-dioxo-4-[1-(2-(trimethylsilanyl)ethoxymethyl)-1H-benzoimidazol-5-yl]imidazolidin-1-yl}-2-(trifluoromethyl)benzonitrile

: 74-88-4
methyl iodide

: 1401225-06-6
4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: 4-{4-methyl-2,5-dioxo-4-[1-(2-(trimethylsilanyl)ethoxymethyl)-1H-benzoimidazol-5-yl]imidazolidin-1-yl}-2-(trifluoromethyl)benzonitrile; methyl iodide; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; methanol; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1401225-06-6
4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) oxide / N,N-dimethyl acetamide / 16 h / 130 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 24 h / 100 °C / Inert atmosphere

With copper(I) oxide; sodium hydride; In N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300281x

Reference yield:

: 1401224-82-5
5-methyl-5-[1-(2-(trimethylsilanyl)ethoxymethyl)-1H-benzoimidazol-5-yl]imidazolidine-2,4-dione

: 1401225-06-6
4-[4-(1H-benzoimidazol-5-yl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) oxide / N,N-dimethyl acetamide / 16 h / 130 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 24 h / 100 °C / Inert atmosphere

With copper(I) oxide; sodium hydride; In N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300281x