H-[L-(αMe)Val]7-OtBu

Base Information

• Chemical Name: H-[L-(αMe)Val]7-OtBu
• CAS No.: 467221-66-5
• Molecular Formula: C₄₆H₈₇N₇O₈
• Molecular Weight: 866.239
• Mol file: 467221-66-5.mol

Synonyms:H-[L-(αMe)Val]7-OtBu

Chemical Property of H-[L-(αMe)Val]7-OtBu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-[L-(αMe)Val]7-OtBu

There total 1 articles about H-[L-(αMe)Val]7-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-α-Methylvaline (4378-19-2,26287-62-7,53940-82-2,53940-83-3) → H-[L-(αMe)Val]7-OtBu (467221-66-5)

Guidance literature:

Multi-step reaction with 12 steps

1: trifluoromethylsulfonyl azide; K₂CO₃; CuSO₄

2: 1-bromo-N,N,2-trimethyl-1-propenylamine / CH₂Cl₂ / 0.25 h

3: 90.2 percent / collidine / CH₂Cl₂ / 0.17 h / 20 °C

4: ammonium formate / Pd/C / methanol / 0.5 h / 20 °C

5: 99 percent / collidine / CH₂Cl₂ / 0.33 h / 20 °C

6: ammonium formate / Pd/C / methanol / 0.5 h / 20 °C

7: 86.9 percent / collidine / CH₂Cl₂ / 0.33 h / 20 °C

8: ammonium formate / Pd/C / methanol / 0.5 h / 20 °C

9: 76.8 percent / collidine / CH₂Cl₂ / 1 h / 20 °C

10: ammonium formate / Pd/C / methanol / 0.5 h / 20 °C

11: 68.5 percent / collidine / CH₂Cl₂ / 2 h / 20 °C

12: ammonium formate / Pd/C / methanol / 0.5 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-bromo-N,N,2-trimethyl-1-propen-1-amine; triflic azide; ammonium formate; potassium carbonate; copper(II) sulfate; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo020280w

Reference yield:

H-[L-(αMe)Val]7-OtBu (467221-66-5) → pBrBz-[L-(αMe)Val]8-OtBu

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine

2: H₂ / catalyst

3: EDC, HOAt

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; catalyst;

Reference yield:

Z-L-(αMe)Val-F (175224-23-4) + H-[L-(αMe)Val]7-OtBu (467221-66-5) → Z-[L-(αMe)Val]8-OtBu (175224-25-6)

Guidance literature:

With 4-methyl-morpholine;

upstream raw materials:

(S)-α-Methylvaline

Downstream raw materials:

Z-[L-(αMe)Val]8-OtBu

Refernces