(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate
CAS No.:1350918-00-1
Molecular Formula:C₃₂H₄₄ClFN₆O₄Si
Molecular Weight:659.276
Hs Code.:

(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Synonyms:(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

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Chemical Property of (R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

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Technology Process of (R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

There total 9 articles about (R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 697739-22-3
2-chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1350917-83-7
(R)-tert-butyl (1-(2-(4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-yl)carbamate

: 1350918-00-1
(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1350918-00-1
(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1350918-00-1
(R)-tert-butyl 1-(2-(4-(2-chloro-6-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: water; lithium hydroxide / 1,4-dioxane / 48 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; N-Bromosuccinimide; water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;