697739-22-3

Basic information

• Product Name: 2-CHLORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 2-CHLORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-Chloro-6-methylpyridine-4-boronic acid,pinacol;2-Chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS NO: 697739-22-3
• Molecular Formula: C₁₂H₁₇BClNO₂
• Molecular Weight: 253.53
• EINECS: 205-525-8
• Mol File: 697739-22-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 354.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.39±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER(697739-22-3)
• EPA Substance Registry System: 2-CHLORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER(697739-22-3)

Safety Data

• Hazardous Substances Data: 697739-22-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-6-methylpyridine-4-boronic acid, pinacol ester

Upstream product

• 1206250-53-4 4-bromo-2-chloro-6-methylpyridine 
• 73183-34-3 bis(pinacol)diborane 
• 18368-63-3 6-chloro-2-picoline 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 42779-75-9 2-chloro-6-methyl-pyridin-4-ol 
• 1321514-06-0 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

The application relates to heterocyclic amide derivatives and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation. (Formula (I))

Multikilogram-Scale Preparation of AZD4635 via C-H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture

An efficient route to AZD4635 has been developed utilizing the Suzuki-Miyaura reaction of a boronate ester prepared by C-H borylation on a multikilogram scale. Preparation of the cross-coupling partner using bromine/pyridine/methanol has highlighted the incompatibility of this reagent/solvent combination with tantalum, which is commonly used in the construction and repair of standard manufacturing vessels.

Microwave-assisted, Ir-catalyzed aromatic C-H borylation

One-step conversions of 1,3-disubstituted benzenes to aryl boronates and 2,6-disubstituted pyridines to heteroaryl boronates are described. Microwave heating was used for all reactions. [(COD)Ir(μ-OMe)]2 and 4,4′-di-tert-butyl-2,2′-bipyridine w