tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

Base Information

Chemical Name:tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate
CAS No.:889675-04-1
Molecular Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.535
Hs Code.:

Synonyms:tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

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Chemical Property of tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

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Technology Process of tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

There total 11 articles about tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1-benzyl-3-chlorooxalyl-2-ethyl-6-methyl-1H-indol-4-yloxy)-acetic acid tert-butyl ester

: 889675-04-1
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

Guidance literature:: With ammonia; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1021/jm060136t

Reference yield:

: 889674-98-0
4-(benzyloxy)-2-ethyl-6-methyl-1H-indole

: 889675-04-1
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.08 h / 0 °C

1.2: 81 percent / dimethylformamide / 2 h

2.1: 78 percent / H₂ / Pd/C / methanol / 2 h / 2068.59 Torr

3.1: NaH / dimethylformamide / 0.08 h / 20 °C

3.2: 87 percent / dimethylformamide / 0.5 h

4.1: CH₂Cl₂ / 2 h / 20 °C

5.1: 0.187 g / NH₃ / CH₂Cl₂ / 0.17 h / 20 °C

With ammonia; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060136t

Reference yield:

: 889674-97-9
1-(4-(benzyloxy)-6-methyl-1H-indol-2-yl)ethanol

: 889675-04-1
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 45 percent / NaBH₄; trifluoroacetic acid / CH₂Cl₂ / 1 h

2.1: NaH / dimethylformamide / 0.08 h / 0 °C

2.2: 81 percent / dimethylformamide / 2 h

3.1: 78 percent / H₂ / Pd/C / methanol / 2 h / 2068.59 Torr

4.1: NaH / dimethylformamide / 0.08 h / 20 °C

4.2: 87 percent / dimethylformamide / 0.5 h

5.1: CH₂Cl₂ / 2 h / 20 °C

6.1: 0.187 g / NH₃ / CH₂Cl₂ / 0.17 h / 20 °C

With sodium tetrahydroborate; ammonia; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060136t