(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

Base Information

Chemical Name:(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran
CAS No.:196600-19-8
Molecular Formula:C₂₂H₃₀O₄
Molecular Weight:358.478
Hs Code.:

Synonyms:(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

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Chemical Property of (E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

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Technology Process of (E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

There total 4 articles about (E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 196600-19-8
(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / PPTS / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) DMPU, n-BuLi, 2.) ZnCl₂, 3.) Pd(PPh₃)4

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; zinc(II) chloride; In dichloromethane;
DOI:10.1055/s-1997-1278

Reference yield:

: 6153-06-6,105-29-3
(E)-3-methylpent-2-en-4-yn-1-ol

: 196600-19-8
(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / PPTS / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) DMPU, n-BuLi, 2.) ZnCl₂, 3.) Pd(PPh₃)4

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; zinc(II) chloride; In dichloromethane;
DOI:10.1055/s-1997-1278

Reference yield:

: 4537-09-1
1,4-dimethoxy-2,3,5-trimethyl-benzene

: 196600-19-8
(E)-2-[5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-2-en-4-yn-1-yl]oxytetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / I₂, H₅IO₆, HOAc, H₂SO₄ / H₂O / 17 h / 45 °C

2: 1.) DMPU, n-BuLi, 2.) ZnCl₂, 3.) Pd(PPh₃)4

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; iodine; acetic acid; periodic acid; zinc(II) chloride; In water;
DOI:10.1055/s-1997-1278