4537-09-1

Upstream product

• 79-21-0 peracetic acid 
• 700-13-0 Trimethylhydroquinone 
• 496-78-6 2,4,5-trimethylphenol 
• 935-92-2 2,3,5-Trimethyl-1,4-benzoquinone 
• 64-19-7 acetic acid 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 1125-21-9 2,6,6-trimethyl-2-cyclohexene-1,4-dione 
• 108-24-7 acetic anhydride 

Downstream Products

• 54757-17-4 1-chloromethyl-2,5-dimethoxy-3,4,6-trimethyl-benzene 
• 72205-69-7 1,1,4,4-Tetramethoxy-2,3,5-trimethyl-2,5-cyclohexadiene 
• 103808-42-0 2,5-dimethoxy-3,4,6-trimethylbenzaldehyde 
• 935-92-2 2,3,5-Trimethyl-1,4-benzoquinone 
• 69821-05-2 1-bromo-2,5-dimethoxy-3,4,6-trimethylbenzene 
• 131426-03-4 1-iodo-2,5-bis(methoxy)-3,4,6-trimethylbenzene 
• 24891-96-1 trimethyl-nitro-[1,4]benzoquinone 
• 17228-90-9 bis(2,5-dimethoxy-3,4,6-trimethylphenyl)methane 
• 864514-98-7 N-[(2,5-dimethoxy-3,4,6-trimethylphenyl)methyl]-2,2,2-trifluoroacetamide 
• 69400-39-1 (+) (S)-6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-carbaldhyde 
• 357172-72-6 3-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-one 
• 357172-73-7 2-[(S)-3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-butyl]-3,5,6-trimethyl-[1,4]benzoquinone 
• 357172-71-5 (S)-4-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol 
• 357172-74-8 (S)-6-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,5,7,8-tetramethyl-chroman 

Relevant academic research and scientific papers

An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications

Antibiotic-resistant infections present significant challenges to patients. As a result, there is considerable need for new antibacterial therapies that eradicate pathogenic bacteria through non-conventional mechanisms. Our group has identified a series o

PREPARATION AND USES OF REACTIVE OXYGEN SPECIES SCAVENGER DERIVATIVES

Compounds of Formula (I) a or (I) b: including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.

SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES

Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-substituted-p-quinone derivatives as disclosed herein.

Preparation method of trimethylhydroquinone

The invention discloses a preparation method of trimethylhydroquinone. The preparation method is characterized in that isophorone is used as an initial raw material and oxidized into oxoisophorone, then an acylation reaction occurs in the oxoisophorone and an acylating agent to produce trimethyl hydroquinone diester, and the trimethyl hydroquinone diester is hydrolyzed to produce 2,3,5-trimethylhydroquinone. The method disclosed by the invention has cheap and easily-available raw materials and simple syntheses steps, a used solvent is easy to recover and reuse, and the method needs not use ofa big amount of acid and alkali, thereby reducing pollution of the environment, being convenient for large-scale industrial production and having good application prospects.

Catalytic Asymmetric Cycloadditions of Silyl Nitronates Bearing α-Aryl Group

1,3-Dipolar cycloadditions of 2-alkylacroleins or atropaldehyde with triisopropylsilyl nitronates bearing an α-aryl group produced 3-aryl-2-isoxazolines having a chiral quaternary center in up to 94% ee and up to 88% yield with the aid of Corey’s oxazaborolidine catalyst. Specifically, the TIPS nitronate with an α-(p-methoxyphenyl) group gave mainly the 2-isoxazolines having an all-carbon quaternary center.

Highly stereoselective construction of the C2 stereocentre of α-tocopherol (Vitamin E) by asymmetric addition of Grignard reagents to ketones

Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77:23 dr (5 steps), 81:19 dr (5 steps) and 96:4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.

QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS

The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.

Total synthesis of (R, R, R)-γ-tocopherol through cu-catalyzed asymmetric 1,2-addition

Based on the asymmetric copper-catalyzed 1,2-addition of Grignard reagents to ketones, (R, R, R)-γ-tocopherol has been synthesized in 36% yield over 12 steps (longest linear sequence). The chiral center in the chroman ring was constructed with 73% ee by the 1,2-addition of a phytol-derived Grignard reagent to an a-bromo enone prepared from 2,3-dimethylquinone.

Hydrindacene-based acetylenic macrocycles with horizontally and vertically ordered functionality arrays

The macrocyclization of 2,6-diethynyl hydrindacenes (1) with functional groups at mutually perpendicular positions results in the formation of novel macrocycles which, as a result of the hindered rotation of the hydrindacene units, possess directionally persistent peripheral functionalities. The two hydrindacene units in the dimer macrocycle (2) have been shown to interact electronically through their respective butadiyne moieties, whereas the trimer macrocycle (3) demonstrates a moderate degree of geometrical flexibility as a result of the five-membered hydrindacene rings. In addition, these trimer macrocycles contain a central cavity suitably sized for the inclusion of various solvent molecules. These new macrocycles can be further modified by introducing π-conjugated side groups, such as styryl and thienyl groups, as well as by attaching a variety of peripheral ester groups. Copyright

Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity

Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.