methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate

Base Information

• Chemical Name: methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate
• CAS No.: 1203507-08-7
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 1203507-08-7.mol

Synonyms:methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate

Chemical Property of methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate

There total 1 articles about methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxy-benzoyl chloride (100-07-2) + methyl 2-aminobutanoate hydrochloride (7682-18-0) → methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate (1203507-08-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.200904333

Reference yield: 100.0%

methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate (1203507-08-7) → DL-(N-(4-methoxybenzoyl))-2-aminobutyric acid (217446-32-7)

Guidance literature:

methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate; With water; sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water;

DOI:10.1002/anie.200904333

Reference yield:

methyl DL-(N-(4-methoxybenzoyl))-2-aminobutanoate (1203507-08-7) → (R,E)-tert-butyl 4-(4-ethyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazol-4-yl)but-2-enoate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol

2: dicyclohexyl-carbodiimide / dichloromethane / 20 °C

3: N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide / toluene / 20 °C / Inert atmosphere

With N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; dichloromethane; toluene;

DOI:10.1021/jacs.5b10524

upstream raw materials:

4-methoxy-benzoyl chloride

methyl 2-aminobutanoate hydrochloride

Downstream raw materials:

DL-(N-(4-methoxybenzoyl))-2-aminobutyric acid

4-ethyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole