1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester
• CAS No.: 784149-57-1
• Molecular Formula: C₂₆H₃₀N₂O₄
• Molecular Weight: 434.535
• Mol file: 784149-57-1.mol

Synonyms:1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester

Chemical Property of 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester

There total 2 articles about 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-40-2) + tert-butyl cyclopropanecarboxylate (87661-20-9) → 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester (784149-57-1)

Guidance literature:

tert-butyl cyclopropanecarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -50 - 0 ℃; for 2.5h;

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine; In tetrahydrofuran; hexanes; for 3h;

Reference yield: 32.0%

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-40-2) + tert-butyl cyclopropanecarboxylate (87661-20-9) + ammonium chloride → 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester (784149-57-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; ethyl acetate;

Reference yield: 40.0%

1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl-methyl}-cyclopropanecarboxylic acid tert-butyl ester (784149-57-1) → 1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-cyclopropanecarboxylic acid

Guidance literature:

With trifluoroacetic acid; In methoxybenzene; at 20 ℃; for 3h;

upstream raw materials:

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine

tert-butyl cyclopropanecarboxylate