(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

Base Information

Chemical Name:(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate
CAS No.:1454273-78-9
Molecular Formula:C₄₁H₄₃F₇N₄O₉
Molecular Weight:868.803
Hs Code.:

(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

Synonyms:(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

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Chemical Property of (R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

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Technology Process of (R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

There total 6 articles about (R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454273-88-1
1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

: 1454273-77-8
(R)-2-((tert-butoxycarbonyl)amino)-2-(4-(2-ethylacetoxy)phenyl)ethyl methanesulfonate

: 1454273-78-9
(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In acetone; at 70 ℃; for 15h;

Reference yield:

: 691889-35-7
(R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycinol

: 1454273-78-9
(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 15 h / 20 - 80 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

With tetrabutylammomium bromide; potassium carbonate; triethylamine; In dichloromethane; acetone;

Reference yield:

: 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester

: 1454273-78-9
(R)-ethyl 2-(4-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; sodium hydrogencarbonate / methanol; dichloromethane / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3: potassium carbonate / acetone / 15 h / 20 - 80 °C

4: triethylamine / dichloromethane / 0.5 h / 20 °C

5: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

With lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;