C₂₉H₃₇F₃N₄O₆S

Base Information

• Chemical Name: C₂₉H₃₇F₃N₄O₆S
• CAS No.: 1306758-55-3
• Molecular Formula: C₂₉H₃₇F₃N₄O₆S
• Molecular Weight: 626.697
• Mol file: 1306758-55-3.mol

Synonyms:C₂₉H₃₇F₃N₄O₆S

Chemical Property of C₂₉H₃₇F₃N₄O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₉H₃₇F₃N₄O₆S

There total 11 articles about C₂₉H₃₇F₃N₄O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2,2-trifluoro-1-(2,8-diazaspiro[4.5]decan-2-yl)ethanone (1242850-29-8) + 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid (1242850-00-5) → C29H37F3N4O6S (1306758-55-3)

Guidance literature:

2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; for 0.25h; Cooling with ice;

2,2,2-trifluoro-1-(2,8-diazaspiro[4.5]decan-2-yl)ethanone; In tetrahydrofuran; at 25 ℃;

Reference yield:

C21H30N2O4 (929301-98-4) → C29H37F3N4O6S (1306758-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

1.2: 0 - 25 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1471.14 Torr

3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / Cooling with ice

3.2: 25 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride (869976-20-5) → C29H37F3N4O6S (1306758-55-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h

2.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

2.2: 0 - 25 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1471.14 Torr

4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / Cooling with ice

4.2: 25 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

2,2,2-trifluoro-1-(2,8-diazaspiro[4.5]decan-2-yl)ethanone

2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

C₂₁H₃₀N₂O₄

tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride

Downstream raw materials:

2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone