2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Base Information

Chemical Name:2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid
CAS No.:1242850-00-5
Molecular Formula:C₁₉H₂₄N₂O₆S
Molecular Weight:408.475
Hs Code.:

Synonyms:2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

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Chemical Property of 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

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Technology Process of 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

There total 9 articles about 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1242850-20-9
ethyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: ethyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate; With water; potassium hydroxide; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; In diethyl ether; water; pH=3;

Reference yield: 81.9%

: 1242850-21-0
tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With citric acid; In water; Product distribution / selectivity;

Reference yield:

: 1242850-16-3
ethyl 2-(2-(1H-pyrrol-1-yl)ethylamino)-2-oxoacetate

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

1.2: pH > 7

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 20 °C

4.2: 0 - 20 °C

5.1: potassium hydroxide; water / ethanol / 16 h / 20 °C

5.2: pH 3

With lithium aluminium tetrahydride; water; sodium hydride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;