4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate
• CAS No.: 1233500-08-7
• Molecular Formula: C₉H₃F₆NO₃S
• Molecular Weight: 319.184
• Mol file: 1233500-08-7.mol

Synonyms:4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate

Chemical Property of 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate

There total 2 articles about 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4-hydroxy-3-(trifluoromethyl)benzonitrile (124811-71-8) → 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate (1233500-08-7)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c7ob02531a

Reference yield: 72.0%

→ 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate (1233500-08-7)

Guidance literature:

Reference yield: 92.0%

isopropylboronic acid (80041-89-0) + 4-cyano-2-(trifluoromethyl)phenyl trifluoromethanesulfonate (1233500-08-7) → 4-isopropyl-3-(trifluoromethyl)benzonitrile

Guidance literature:

With potassium phosphate; [Pd(cinnamyl)Cl]₂; C₂₁H₃₇NO₂P₂; In toluene; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c7ob02531a

upstream raw materials:

trifluoromethylsulfonic anhydride

4-hydroxy-3-(trifluoromethyl)benzonitrile

Downstream raw materials:

tert-butyl 3-(4-cyano-2-(trifluoromethyl)phenyl)acrylate