(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

Base Information

Chemical Name:(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one
CAS No.:1034276-32-8
Molecular Formula:C₁₆H₁₄O₆
Molecular Weight:302.284
Hs Code.:

Synonyms:(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

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Technology Process of (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

There total 6 articles about (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: C₂₀H₂₂O₈

: 1034276-32-8
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

Guidance literature:: With hydrogenchloride; In methanol; water; for 0.5h; Inert atmosphere; Reflux;
DOI:10.1021/jm5016507

Reference yield: 71.0%

: 1034276-40-8
C₂₄H₃₀O₁₀

: 1034276-32-8
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

Guidance literature:: With hydrogenchloride; In methanol; for 0.25h; Heating;
DOI:10.1016/j.bmc.2008.02.079

Reference yield:

: 108-73-6
3,5-dihydroxyphenol

: 1034276-32-8
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / 36 h / Inert atmosphere; Heating

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

4: potassium hydroxide / 0.08 h / 20 °C / Inert atmosphere

5: hydrogenchloride / methanol; water / 0.5 h / Inert atmosphere; Reflux

With hydrogenchloride; boron trifluoride diethyl etherate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 4: |Claisen-Schmidt Condensation;
DOI:10.1021/jm5016507