5-chloro-1-methyl-1H-indole-2-carbaldehyde

Base Information

• Chemical Name: 5-chloro-1-methyl-1H-indole-2-carbaldehyde
• CAS No.: 883529-71-3
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.633
• Mol file: 883529-71-3.mol

Synonyms:5-chloro-1-methyl-1H-indole-2-carbaldehyde

Chemical Property of 5-chloro-1-methyl-1H-indole-2-carbaldehyde

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-1-methyl-1H-indole-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 26-45

MSDS Files:

Useful:

Technology Process of 5-chloro-1-methyl-1H-indole-2-carbaldehyde

There total 6 articles about 5-chloro-1-methyl-1H-indole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(5-chloro-1-methyl-1H-indol-2-yl)methanol (211060-53-6) → 5-chloro-1-methyl-1H-indole-2-carbaldehyde (883529-71-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00895

Reference yield:

ethyl 5-chloro-1-methyl-1H-indole-2-carboxylate (59908-53-1) → 5-chloro-1-methyl-1H-indole-2-carbaldehyde (883529-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201502553

Reference yield:

5-chloro-indole-2-carboxylic acid ethyl ester (4792-67-0) → 5-chloro-1-methyl-1H-indole-2-carbaldehyde (883529-71-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.orglett.7b00914

upstream raw materials:

ethyl 5-chloro-1-methyl-1H-indole-2-carboxylate

(5-chloro-1-methyl-1H-indol-2-yl)methanol

5-chloro-1H-Indole-2-carboxylic acid

methyl 5-chloro-1-methyl-1H-indole-2-carboxylate