3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one

Base Information

• Chemical Name: 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one
• CAS No.: 1621478-77-0
• Molecular Formula: C₂₃H₁₂F₆O₂
• Molecular Weight: 434.337
• Mol file: 1621478-77-0.mol

Synonyms:3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one

Chemical Property of 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one

There total 4 articles about 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N,N-diethyl-O-benzoylhydroxylamine (61582-64-7) + 1,2-bis(4-(trifluoromethyl)phenyl)ethyne (119757-51-6) → 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one (1621478-77-0)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In 2,2,2-trifluoroethanol; at 60 ℃; for 16h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201400200

Reference yield: 68.0%

p-(trifluoromethyl)benzenediazonium tetrafluoroborate + methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate (107793-07-7) → 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one (1621478-77-0)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; (triphenylphosphine)gold(I) chloride; In methanol; acetonitrile; at -78 - 20 ℃; for 1h; Schlenk technique; Irradiation; Inert atmosphere;

DOI:10.1002/adsc.201700427

Reference yield: 55.0%

tert-Butyl peroxybenzoate (614-45-9) + 1,2-bis(4-(trifluoromethyl)phenyl)ethyne (119757-51-6) → 3,4-bis(4-(trifluoromethyl)phenyl)-1H-isochromen-1-one (1621478-77-0)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium pivalate; Trimethylacetic acid; In 2,2,2-trifluoroethanol; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02291

upstream raw materials:

N,N-diethyl-O-benzoylhydroxylamine

1,2-bis(4-(trifluoromethyl)phenyl)ethyne

benzoyl chloride

tert-Butyl peroxybenzoate