PROPIO-2,2-D2-PHENONE

Base Information

• Chemical Name: PROPIO-2,2-D2-PHENONE
• CAS No.: 129848-87-9
• Molecular Formula: C9H8 D2 O
• Molecular Weight: 136.162
• Mol file: 129848-87-9.mol

Synonyms:PROPIO-2,2-D2-PHENONE

Chemical Property of PROPIO-2,2-D2-PHENONE

Chemical Property:

• PSA: 17.07000
• LogP: 2.27930

Purity/Quality:

99% ^*data from raw suppliers

Propio-2,2-d2-phenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Propio-2,2-d2-phenone (CAS# 129848-87-9) is a useful isotopically labeled research compound.

Technology Process of PROPIO-2,2-D2-PHENONE

There total 6 articles about PROPIO-2,2-D2-PHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenyl-propan-1-one (93-55-0) → propiophenone-α,α-d2 (129848-87-9)

Guidance literature:

With potassium tert-butylate; water-d2; In 1,4-dioxane; for 4h; Heating;

Reference yield:

1-phenyl-propan-1-one (93-55-0) → propiophenone-α,α-d2 (129848-87-9) + propiophenone-α-d1 (76973-09-6)

Guidance literature:

With deuteromethanol; sodium methylate; at 20 ℃; for 144h;

DOI:10.1021/ja064927w

Reference yield:

2,2-dibromo-1-phenylpropan-1-one (2114-03-6) → C9H8(2)HBrO + propiophenone-α,α-d2 (129848-87-9)

Guidance literature:

With water-d2; 1-methyl-3-pentyl-1H-imidazolium tetrafluoroborate; at 125 ℃; for 0.0666667h; under 2585.74 Torr; Title compound not separated from byproducts; microwave irradiation;

DOI:10.1016/j.tet.2006.10.035

upstream raw materials:

1-phenyl-propan-1-one

2,2-dibromo-1-phenylpropan-1-one

1-Phenylprop-1-yne

d⁽⁴⁾-methanol

Downstream raw materials:

N,N-dimethyl hydrazone de la propiophenone (d2-2)

(2,2-dideuterio-propyl)-benzene

(2-deuterio-propenyl)-benzene

Refernces

• 1、 Zhang, Sheng,Bedi, Deepika,Cheng, Lu,Unruh, Daniel K.,Li, Guigen,Findlater, Michael. "Cobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes". supporting information. p. 8910 - 8917. Retrieved 2020/12/23.
• 2、 Zhao, Jiajin,Cheng, Biao,Chen, Chenhui,Lu, Zhan. "Cobalt-Catalyzed Migrational Isomerization of Styrenes". supporting information. p. 837 - 841. Retrieved 2020/01/31.