1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

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Chemical Name:1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine
CAS No.:1439392-96-7
Molecular Formula:C₂₆H₂₂F₃N₇O
Molecular Weight:505.502
Hs Code.:

Synonyms:1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

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Technology Process of 1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

There total 4 articles about 1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439393-02-8
(1-{4-[8-(2-methyl-2H-pyrazol-3-yl)-2-(3-trifluoromethoxy-phenyl)-purin-9-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1439392-96-7
1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1439392-98-9
(1-{4-[5-amino-2-(3-trifluoromethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1439392-96-7
1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: copper diacetate; acetic acid / 2 h / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; copper diacetate; acetic acid; In ethyl acetate;

Reference yield:

: 1259224-00-4
[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1439392-96-7
1-(4-(8-(1-methyl-1H-pyrazol-5-yl)-2-(3-(trifluoromethoxy)phenyl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere

3: copper diacetate; acetic acid / 2 h / 100 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper diacetate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;