5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine
CAS No.:1020100-92-8
Molecular Formula:C₄₁H₄₁Cl₂N₃O₁₀
Molecular Weight:806.697
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

There total 9 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1020100-87-1
2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1020100-92-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

Guidance literature:: With pyridine; at 25 ℃; for 2h;
DOI:10.1021/jo702717g

Reference yield:

: 1020100-86-0
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

: 1020100-92-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium fluoride / methanol / 16 h / 25 °C

2: pyridine / 2 h / 25 °C

With pyridine; ammonium fluoride; In methanol;
DOI:10.1021/ol0629824

Reference yield:

: C₁₁H₁₉NOSi

: 1020100-92-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[4-[N-(dichloroacetyl)-N-methylamino]benzyl]oxy]methyl]uridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂ / 2 h / 25 °C

1.2: H₂O / CH₂Cl₂; methanol / 1 h / 25 °C

2.1: N-iodosuccinimide; trifluoromethanesulfonic acid / 1,2-dichloro-ethane; diethyl ether / 0 °C

3.1: ammonium fluoride / methanol / 16 h / 25 °C

4.1: pyridine / 2 h / 25 °C

With pyridine; N-iodo-succinimide; ammonium fluoride; trifluorormethanesulfonic acid; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol0629824