leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate

Base Information

• Chemical Name: leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate
• CAS No.: 137043-75-5
• Molecular Formula: C₇H₈O₃S*C₃₁H₅₁N₇O₈S
• Molecular Weight: 854.059

Synonyms:leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate

Chemical Property of leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate

Chemical Property:

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Technology Process of leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate

There total 1 articles about leucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Nα-benzyloxycarbonylleucinyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester (112160-35-7) + toluene-4-sulfonic acid (104-15-4) → leucinyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate (137043-75-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4020(01)86564-9

Reference yield:

Nα-benzyloxycarbonyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-L-arginine (112160-32-4) + leucinyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester tosylate (137043-75-5) → Nα-benzyloxycarbonyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylleucinyl-NG-(2,2,5,7,8-pentamethylchroman-6 sulphonyl)-arginylglycylglycine methyl ester (112160-34-6)

Guidance literature:

With 4-methyl-morpholine; 2,6-dimethylpyridine; Diphenylphosphinic chloride; Yield given. Multistep reaction; 1.) DCM, -5 deg C, 2 min 2.) DMF a) -10 deg C, 1 h b) -10 deg C -> rt, 3 h c) rt, 1 h;

DOI:10.1016/S0040-4020(01)86564-9

upstream raw materials:

N^α-benzyloxycarbonylleucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylglycylglycine methyl ester

toluene-4-sulfonic acid

Downstream raw materials:

N^α-benzyloxycarbonyl-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylleucinyl-N^G-(2,2,5,7,8-pentamethylchroman-6 sulphonyl)-arginylglycylglycine methyl ester

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