(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate
CAS No.:1438218-64-4
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1007882-59-8
(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 5720-07-0
4-methoxyphenylboronic acid

: 1438218-64-4
(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

Guidance literature:: With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; palladium diacetate; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere; Glovebox;
DOI:10.1021/jo501326r

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1438218-64-4
(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

2.2: 12 h / 20 °C

3.1: ammonium acetate / toluene / 16 h / Reflux

With ammonium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1438218-64-4
(S)-tert-butyl 2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

2.2: 12 h / 20 °C

3.1: ammonium acetate / toluene / 16 h / Reflux

With ammonium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; toluene;