(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

Base Information

Chemical Name:(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol
CAS No.:1263371-46-5
Molecular Formula:C₂₂H₂₂ClFN₄O
Molecular Weight:412.894
Hs Code.:

Synonyms:(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

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Chemical Property of (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

Chemical Property:

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Technology Process of (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

There total 5 articles about (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036260-18-0,167298-58-0
(1S,3R)-3-aminocyclopentane-1-ol

: 1263374-08-8
5'-chloro-2'-fluoro-N-(3-fluorobenzyl)-[2,4'-dipyridine]-6-amine

: 1263371-46-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

Guidance literature:: (1S,3R)-3-aminocyclopentane-1-ol; 5'-chloro-2'-fluoro-N-(3-fluorobenzyl)-2,4'-bipyridin-6-amine; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h;

With sodium hydroxide; In ethyl acetate;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1263371-46-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 168 h / 115 - 120 °C / Inert atmosphere

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 3 h / 100 °C

3: triethylamine / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C

With sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; 2: Suzuki Coupling;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 1263371-46-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 168 h / 115 - 120 °C / Inert atmosphere

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 3 h / 100 °C

3: triethylamine / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C

With sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; 2: Suzuki Coupling;