N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

Base Information

Chemical Name:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide
CAS No.:1101118-99-3
Molecular Formula:C₂₁H₂₄N₈O₄S
Molecular Weight:484.539
Hs Code.:

Synonyms:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

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Chemical Property of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

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Technology Process of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

There total 5 articles about N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1101118-97-1
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methyl-5-nitrobenzenesulfonohydrazide

: 142-25-6
N,N',N'-trimethylenediamine

: 1101118-99-3
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methyl-5-nitrobenzenesulfonohydrazide; N,N',N'-trimethylenediamine; In tetrahydrofuran; for 18h;

With hydrogenchloride; In methanol; dichloromethane; for 0.5h;
DOI:10.1016/j.bmcl.2016.11.078

Reference yield:

: 1101120-03-9
pyrazolo[1,5-a]pyridine-5-carboxamide

: 1101118-99-3
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 18.5 h / 0 - 20 °C

1.2: 1 h / 0 °C / pH 10

2.1: 2,6-dimethylpyridine / methanol / 1 h

2.2: 2 h

3.1: tetrahydrofuran / 3 h

With 2,6-dimethylpyridine; trichlorophosphate; In tetrahydrofuran; methanol; 1.1: Vilsmeier Formylation;

Reference yield:

: 1101120-00-6
3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

: 1101118-99-3
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-((2-(dimethylamino)ethyl)(methyl)amino)-N-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; water / 16 h / Heating / reflux

1.2: 0 °C / pH 2

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h

2.2: 2 h / 0 °C

3.1: trichlorophosphate / 18.5 h / 0 - 20 °C

3.2: 1 h / 0 °C / pH 10

4.1: 2,6-dimethylpyridine / methanol / 1 h

4.2: 2 h

5.1: tetrahydrofuran / 3 h

With 2,6-dimethylpyridine; sulfuric acid; water; 1,1'-carbonyldiimidazole; trichlorophosphate; In tetrahydrofuran; methanol; 3.1: Vilsmeier Formylation;