Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester

Base Information

Chemical Name:Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester
CAS No.:1101120-00-6
Molecular Formula:C₁₂H₁₂N₂O₄
Molecular Weight:248.238
Hs Code.:
Mol file:1101120-00-6.mol

Synonyms:Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester;3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Suppliers and Price of Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
3-ethyl5-methylpyrazolo[1,5-a]pyridine-3,5-dicarboxylate
250mg
$ 659.60

Total 3 raw suppliers

Chemical Property of Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester

Chemical Property:

PKA:-0.62±0.30(Predicted)
PSA：69.90000
Density:1.30±0.1 g/cm3(Predicted)
LogP:1.29760

Purity/Quality:

98%min ^*data from raw suppliers

3-ethyl5-methylpyrazolo[1,5-a]pyridine-3,5-dicarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester

There total 2 articles about Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3-ethyl 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 623-47-2
propynoic acid ethyl ester

: 1101120-00-6
3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Guidance literature:: 4-pyridinecarboxylic acid, methyl ester; With O-(2,4-dinitrophenyl)hydroxylamine; In N,N-dimethyl-formamide; at 40 ℃;

propynoic acid ethyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 42.0%

: 1101120-00-6
3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Guidance literature:

Reference yield:

: 1101120-00-6
3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

: 1101118-71-1
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; water / 18 h / Reflux

1.2: pH 2

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C

2.2: 1.03 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / 20 °C / Inert atmosphere

3.2: pH 10

4.1: methanol / 18 h / 20 °C

With sulfuric acid; water; triethylamine; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; methanol; 3.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.11.029