N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Base Information

Chemical Name:N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine
CAS No.:1160682-82-5
Molecular Formula:C₁₇H₁₀BrF₂N₃O₄
Molecular Weight:438.185
Hs Code.:

Synonyms:N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

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Chemical Property of N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

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Technology Process of N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

There total 7 articles about N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1160682-84-7
7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1160682-82-5
N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: 7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid; glycine ethyl ester hydrochloride; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

With water; sodium hydroxide; In ethanol; at 20 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160682-82-5
N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

5.2: 0.33 h / 100 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20 °C

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

7.2: 1 h / 20 °C

With ammonium hydroxide; tin(II) chloride dihdyrate; sulfuric acid; bromine; nitric acid; boron tribromide; sodium hydride; triethylamine; HATU; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160682-82-5
N-{[7-bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

3.2: 0.33 h / 100 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.2: 1 h / 20 °C

With tin(II) chloride dihdyrate; bromine; boron tribromide; sodium hydride; triethylamine; HATU; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;