7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

Base Information

Chemical Name:7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid
CAS No.:1160682-84-7
Molecular Formula:C₁₅H₇BrF₂N₂O₃
Molecular Weight:381.133
Hs Code.:

Synonyms:7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

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Chemical Property of 7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

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Technology Process of 7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

There total 6 articles about 7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1160682-83-6
Methyl 7-bromo-3-(2,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

: 1160682-84-7
7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

Guidance literature:: Methyl 7-bromo-3-(2,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate; With boron tribromide; In dichloromethane; at 20 ℃;

With water; In dichloromethane;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160682-84-7
7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

5.2: 0.33 h / 100 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20 °C

With ammonium hydroxide; tin(II) chloride dihdyrate; sulfuric acid; bromine; nitric acid; boron tribromide; sodium hydride; In ethanol; dichloromethane; water; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160682-84-7
7-Bromo-3-(2,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

3.2: 0.33 h / 100 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 20 °C

With tin(II) chloride dihdyrate; bromine; boron tribromide; sodium hydride; In ethanol; dichloromethane; mineral oil;