benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

Base Information

Chemical Name:benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate
CAS No.:885514-93-2
Molecular Formula:C₃₀H₃₆N₂O₄
Molecular Weight:488.627
Hs Code.:

Synonyms:benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

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Chemical Property of benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

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Technology Process of benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

There total 5 articles about benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 936827-67-7
benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

: 5469-26-1
1-Bromopinacolon

: 885514-93-2
benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-Bromopinacolon; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm051219x

Reference yield:

: 885514-92-1
benzyl (S)-3-((2-cyclohexylcarbonyl)phenylcarbamoyl)-3-aminopropanoate

: 885514-93-2
benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / ammonium acetate; acetic acid / 24 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 61 percent / dimethylformamide / 2 h / 20 °C

With ammonium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm051219x

Reference yield:

: 885514-91-0
tert-butyl (S)-2-((benzyloxy)carbonyl)-1-((2-cyclohexylcarbonyl)phenylcarbamoyl)ethylcarbamate

: 885514-93-2
benzyl 2-((S)-5-cyclohexyl-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / trifluoroacetic acid / 1 h / 20 °C

2.1: 77 percent / ammonium acetate; acetic acid / 24 h / 20 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 61 percent / dimethylformamide / 2 h / 20 °C

With ammonium acetate; sodium hydride; acetic acid; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm051219x