4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

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Chemical Name:4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid
CAS No.:1444121-74-7
Molecular Formula:C₁₉H₂₃ClN₈O₃
Molecular Weight:446.896
Hs Code.:

Synonyms:4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

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Chemical Property of 4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

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Technology Process of 4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

There total 5 articles about 4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444124-26-8
C₂₃H₃₁ClN₈O₃

: 1444121-74-7
4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1444121-74-7
4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

1.2: 4 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; tert-butyl methyl ether / 20 °C

3.1: triethylamine / tetrahydrofuran

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With trifluorormethanesulfonic acid; water; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether;

Reference yield:

: 1458-01-1
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester

: 1444121-74-7
4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 3 h / Reflux

2.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

2.2: 4 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; tert-butyl methyl ether / 20 °C

4.1: triethylamine / tetrahydrofuran

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With trifluorormethanesulfonic acid; water; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether;