methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

Base Information

Chemical Name:methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate
CAS No.:1202927-90-9
Molecular Formula:C₁₈H₁₅F₄N₃O₃
Molecular Weight:397.329
Hs Code.:

Synonyms:methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

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Chemical Property of methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

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Technology Process of methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

There total 2 articles about methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1202927-93-2
methyl 2-(2-oxoimidazolidin-1-yl)isonicotinate

: 2250-36-4
1-(bromodifluoromethyl)-4-(difluoromethyl)benzene

: 1202927-90-9
methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

Guidance literature:: methyl 2-(2-oxoimidazolidin-1-yl)isonicotinate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

1-(bromodifluoromethyl)-4-(difluoromethyl)benzene; In N,N-dimethyl-formamide; mineral oil; at 0 - 60 ℃;

Reference yield:

: 6937-03-7
methyl 2-aminoisonicotinate

: 1202927-90-9
methyl 2-(3-((4-(difluoromethyl)phenyl)difluoromethyl)-2-oxoimidazolidin-1-yl)isonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 h / 20 °C / Reflux

2.1: potassium carbonate; triethylamine / tetrahydrofuran / 23 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 0 - 60 °C

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;