(S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate

Base Information

• Chemical Name: (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate
• CAS No.: 875151-91-0
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₁N₃O
• Molecular Weight: 457.452
• Mol file: 875151-91-0.mol

Synonyms:(S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate

Chemical Property of (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate

There total 3 articles about (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-1-(1H-benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (875151-88-5) + trifluoroacetic acid (76-05-1) → (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate (875151-91-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) → (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate (875151-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 72 h / 120 - 140 °C

2.1: dichloromethane / 2 h / 20 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1,2-diamino-benzene (95-54-5) → (S)-1-(1H-Benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate (875151-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 72 h / 120 - 140 °C

2.1: dichloromethane / 2 h / 20 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

[(S)-1-(1H-benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

trifluoroacetic acid

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

1,2-diamino-benzene