875151-88-5Relevant academic research and scientific papers
An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology
Barasa, Leonard,Yoganathan, Sabesan
, p. 35824 - 35830 (2018)
Benzimidazole is a privileged, and routinely used pharmacophore in the drug discovery process. Herein, we report a mild, acid-free and one-pot synthesis of indole, alkyl and alpha-amino benzimidazoles through a novel HBTU-promoted methodology. An extensive library of indole-carboxylic acids, alkyl carboxylic acids and N-protected alpha-amino acids has been converted into the corresponding benzimidazoles in 80-99% yield. Since alpha-aminobenzimidazoles are highly useful synthons as chiral ligands for chemical catalysis, as well as for drug discovery endeavors, our reported method provides direct access to this scaffold in a simple, one-pot operation from commercially available carboxylic acids.
FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF
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Page/Page column 18; 47, (2008/12/06)
A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, R2, R3 and
FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF
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Page/Page column 89, (2010/02/15)
A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of Formula (I), wherein, R, R1, R2, R3 a
