4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Base Information

Chemical Name:4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester
CAS No.:1123157-58-3
Molecular Formula:C₂₉H₅₀O₆Si
Molecular Weight:522.798
Hs Code.:

Synonyms:4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

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Chemical Property of 4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

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Technology Process of 4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

There total 10 articles about 4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1123157-57-2
4-[3-[6-(tert-butyldimethylsilanyloxy)hex-1-enyl]-2-((E)-2-ethoxycarbonylvinyl)phenoxy]butyric acid ethyl ester

: 1123157-58-3
4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 36h;

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1123157-58-3
4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2: sodium ethanolate / ethanol / 48 h / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

With dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); hydrogen; sodium ethanolate; palladium 10% on activated carbon; In ethyloxirane; ethanol; water; ethyl acetate; chlorobenzene; acetonitrile; 2: Horner-Wadsworth-Emmons Olefination / 4: Wittig Reaction / 5: Wittig Reaction;

Reference yield:

: 1123157-53-8
4-(2-formyl-3-methylphenoxy)butyric acid ethyl ester

: 1123157-58-3
4-[3-[6-(tert-butyldimethylsilanyloxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / 48 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

3: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

4: ethyloxirane; acetonitrile / 15 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; sodium ethanolate; palladium 10% on activated carbon; In ethyloxirane; ethanol; ethyl acetate; chlorobenzene; acetonitrile; 1: Horner-Wadsworth-Emmons Olefination / 3: Wittig Reaction / 4: Wittig Reaction;